CD10 and CD20 Expression in a Primary Cutaneous Lymphoma of Mature T Cell CD8 Phenotype.
Identifieur interne : 008506 ( Main/Exploration ); précédent : 008505; suivant : 008507CD10 and CD20 Expression in a Primary Cutaneous Lymphoma of Mature T Cell CD8 Phenotype.
Auteurs : K. Seilstad ; P. Porcu [États-Unis] ; K. Gupta ; C. MagroSource :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
Introduction: Most primary cutaneous T cell lymphomas are derived from mature T lymphocytes. We encountered a case of primary cutaneous T cell lymphoma with an undescribed phenotypic profile as defined by CD3+, CD8+ lymphocytes that co‐expressed CD10, CD20 and CD30. Results: The patient, a 65‐year‐old woman, presented in 2001 with a thigh mass that was biopsied and held to represent a lymphoblastic T cell lymphoma based on CD10 expression. Two years later the patient developed a recurrence. The pathology showed a large cell lymphoma manifesting a CD8 phenotype although with CD10/CD20 expression. Conclusion: The importance in this case lies in the novel phenotype, namely a mature post thymic T cell lymphoma exhibiting CD10 and CD20 positivity. CD10 expression in primary cutaneous T cell lymphoma in the literature is largely limited to two case reports. CD10, a neutral endopeptidase, cleaves proteins with inflammatory or proinflammatory activity released by dying malignant and benign T cells including those of post thymic origin and may also degrade cytokines which inhibit T‐cell apoptosis. Another unique aspect of our case was CD20 positivity whereby only a small number of prior citations exist, all with a CD8 phenotype as was the case in our patient.
Url:
DOI: 10.1111/j.0303-6987.2005.320gs.x
Affiliations:
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Seilstad</name><affiliation><wicri:noCountry code="no comma">Department of Pathology and the Department of Internal Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Porcu, P" sort="Porcu, P" uniqKey="Porcu P" first="P" last="Porcu">P. Porcu</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>, The Ohio State University, Columbus, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Gupta, K" sort="Gupta, K" uniqKey="Gupta K" first="K" last="Gupta">K. Gupta</name><affiliation><wicri:noCountry code="no comma">Department of Pathology and the Department of Internal Medicine</wicri:noCountry></affiliation></author><author><name sortKey="Magro, C" sort="Magro, C" uniqKey="Magro C" first="C" last="Magro">C. Magro</name><affiliation><wicri:noCountry code="no comma">Department of Pathology and the Department of Internal Medicine</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="ISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="115">115</biblScope><biblScope unit="page" to="115">115</biblScope><biblScope unit="page-count">1</biblScope><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-01">2005-01</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Introduction: Most primary cutaneous T cell lymphomas are derived from mature T lymphocytes. We encountered a case of primary cutaneous T cell lymphoma with an undescribed phenotypic profile as defined by CD3+, CD8+ lymphocytes that co‐expressed CD10, CD20 and CD30. Results: The patient, a 65‐year‐old woman, presented in 2001 with a thigh mass that was biopsied and held to represent a lymphoblastic T cell lymphoma based on CD10 expression. Two years later the patient developed a recurrence. The pathology showed a large cell lymphoma manifesting a CD8 phenotype although with CD10/CD20 expression. Conclusion: The importance in this case lies in the novel phenotype, namely a mature post thymic T cell lymphoma exhibiting CD10 and CD20 positivity. CD10 expression in primary cutaneous T cell lymphoma in the literature is largely limited to two case reports. CD10, a neutral endopeptidase, cleaves proteins with inflammatory or proinflammatory activity released by dying malignant and benign T cells including those of post thymic origin and may also degrade cytokines which inhibit T‐cell apoptosis. Another unique aspect of our case was CD20 positivity whereby only a small number of prior citations exist, all with a CD8 phenotype as was the case in our patient.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Ohio</li></region></list><tree><noCountry><name sortKey="Gupta, K" sort="Gupta, K" uniqKey="Gupta K" first="K" last="Gupta">K. Gupta</name><name sortKey="Magro, C" sort="Magro, C" uniqKey="Magro C" first="C" last="Magro">C. Magro</name><name sortKey="Seilstad, K" sort="Seilstad, K" uniqKey="Seilstad K" first="K" last="Seilstad">K. Seilstad</name></noCountry><country name="États-Unis"><region name="Ohio"><name sortKey="Porcu, P" sort="Porcu, P" uniqKey="Porcu P" first="P" last="Porcu">P. Porcu</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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